The Dengue virus (DEN) is of the genus Flavivirus and possesses a positive-strand RNA genome of approximately 10.6 kb that contains a single open-reading frame encoding for a polyprotein， which can be further cleaved by cellular and viral proteases into three structural proteins (capsid protein C, membrane protein M, envelope protein E), and seven non-structural proteins (NS 1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). There are four serotypes (DEN 1-4), though there is certainly genotypic variability in individual viral genomes within each serotype. This variability is thought to have minimal clinical significance , as human infection from any of the four serotypes results in long-term immunity to that serotype . However, cross-immunity between serotypes is of much shorter duration , meaning that many people are victims of sequential infection by different serotypes. This is clinically very important, as sequential infection appears to be a risk factor for more serious disease manifestations.
Dengue Virus Protein Schematic Diagram (Non-Structural Proteins (Orange)
Dengue virus 1, 2, 3 & 4 antibody [D1-11 (3)] (GTX29202) NS1 (Dengue virus ) antibody [GT1 061] (GTX630SS7)
Dengue virus antibody detects Dengue virus 1 protein at NS1 antibody detects NS1 (Dengue virus) protein at
cytoplasm by immunofluorescent analysis cytoplasm by immunofluorescent analysis
Envelope protein (Dengue virus) antibody [GT214] (GTX629116) WB analysis for all blots
Envelope protein antibody detects Envelope protein (Dengue A: BHK-21; B: DEN2-infecled BHK-21; C: JEV-infecled BHK
virus) protein at cytoplasm by immunofluorescent analysis -21 Blols probed wilh Rb pAb 10 (Ieft 10 righl): NS1 (GTX124
280); NS2B (GTX124246); NS3 (GTX124252); NS4B (GTX124
280); NS2B (GTX124246); NS3 (GTX124252); NS4B (GTX124
250); NS5 (GTX124253)
|
Cat.NO
|
Product
|
Reactivity
|
Host&Clonality
|
Application
|
|
GTX29202
|
Dengue Virus 1, 2, 3 & 4 antibody [D1-11(3)]
|
DEN
|
Ms mAb IgG2a
|
Dot blot, ELlSA, ICC/IF, WB
|
|
GTX41428
|
Dengue Virus Type 2 antibody [NYRDeng2]
|
DEN2
|
Ms mAb IgG1
|
ELISA. WB
|
|
GTX43295
|
Dengue Types 1,2,3,4 antibody [BDI419]
|
DEN
|
Ms mAb IgG2a
|
Dot blot, ELlSA, ICC川F
|
|
GTX41437
|
Dengue Virus antibody [5161]
|
DEN
|
Ms mAb IgG2a
|
ELISA
|
|
GTX41430
|
Dengue Virus Type 2 antibody [3H5.1]
|
DEN2
|
Ms mAb IgG1
|
ICC/IF
|
|
GTX43296
|
Dengue Type 2, envelope antibody [B932M]
|
DEN2
|
Ms mAb IgG1
|
ICC/IF
|
|
GTX124247
|
Capsid Protein (Dengue Virus) antibody
|
Capsid (DEN)
|
Rb pAb
|
WB
|
|
GTX103343
|
Capsid Protein (Dengue Virus) antibody
|
Capsid (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX128092
|
PrM (Dengue Virus) antibody
|
PrM (DEN)
|
Rb pAb
|
WB
|
|
GTX128093
|
PrM (Dengue Virus) antibody
|
PrM (DEN)
|
Rb pAb
|
WB
|
|
GTX127277
|
Envelope protein (Dengue Virus) antibody
|
Envelope (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX629116
|
Envelope protein (Dengue Virus) antibody [GT214]
|
Envelope (DEN)
|
Ms mAb IgG2a
|
ICC/IF. WB
|
|
GTX629117
|
Envelope protein (Dengue Virus) antibody [GT643]
|
Envelope (DEN)
|
Ms mAb IgG2b
|
ICC/IF. WB
|
|
GTX630557
|
NS1 (Dengue virus) antibody [GT1061]
|
NS1 (DEN)
|
Ms mAb IgG1(NEW Producr)
|
ICC/IF. WB
|
|
GTX630556
|
NS1 (Dengue virus) antibody [GT4212]
|
NS1 (DEN)
|
Ms mAb IgG2a(NEW Producr)
|
ICC/IF. WB
|
|
GTX103346
|
NS1 (Dengue Virus 2) antibody
|
NS1 (DEN2)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX124280
|
NS1 (Dengue Virus) antibody
|
NS1 (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX124246
|
NS2B (Dengue Virus) antibody
|
NS2B (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX124252
|
NS3 (Dengue Virus) antibody
|
NS3 (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX629477
|
NS3 (Dengue Virus) antibody [GT2811]
|
NS3 (DEN)
|
Ms mAb IgG1
|
ICC/IF. WB
|
|
GTX124249
|
NS4A (Dengue Virus) antibody
|
NS4A (DEN)
|
Rb pAb
|
WB
|
|
GTX103349
|
NS4B (Dengue Virus) antibody
|
NS4B (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX124250
|
NS4B (Dengue Virus) antibody
|
NS4B (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX103350
|
NS5 (Dengue Virus) antibody
|
NS5 (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX124253
|
NS5 (Dengue Virus) antibody
|
NS5 (DEN)
|
Rb pAb
|
ICC/IF. WB
|
|
GTX629446
|
NS5 (Dengue Virus 2) antibody [GT353]
|
NS5 (DEN)
|
Ms mAb IgG2b
|
ICC/IF. WB
|
|
GTX629447
|
NS5 (Dengue Virus 2) antibody [GT361]
|
NS5 (DEN)
|
Ms mAb IgG1
|
ICC/IF. WB
|
serotypes. All four dengue serotypes circulate together in tropical and subtropical regions around the world.
Three are structural proteins: the capsid (C), envelope (E), and membrane (M) proteins. Seven are nonstructural proteins: NS1, NS2A,
NS2B, NS3, NS4A, NS4B, and NS5. These nonstructural proteins play roles in viral replication and assembly.
| Proteins | Functions | GeneTex Antibodies | |
|
Structure Proteins |
Capsid |
Encapsidation of the RNA genome. May regulate host cell apoptosis through stabilizing P53 |
GTX124247, GTX103343 |
| Envelope |
Allowing virus to enter host cells. Essential target of antiviral vaccine ★. |
GTX43296 | |
| Membrane | Compose viral membrane structure |
GTX127277, GTX629116, GTX629117, |
|
|
Non-Structure Proteins |
NS1 |
Essential for virus replication, as a target of humural immunity. |
GTX630556, GTX630557, GTX103346, GTX124280, |
| NS2A, 2B |
Viral RNA synthesis, virion assembly/maturation, and antagonizes the host immune response |
GTX124246 (2B) | |
| NS3 |
Protease/ nucleotide triphosphatases and helicase activity used for viral RNA synthesis. |
GTX124252, GTX629477, | |
| NS4A, 4B |
Blocking IFNa/b signaling and involved in STAT pathway in host cells. |
GTX124249 (4A), GTX103349 (4B), GTX124250 (4B) |
|
| NS5 | Viral RNA polymerase and methyltransferase. |
GTX103350, GTX124253, GTX629446, GTX629447 |
|
|
GeneTex Antibodies against whole virons |
GTX29202, GTX41428, GTX43295, GTX41437, GTX41430 | ||
