人体内的细菌数量是人体细胞的10倍。这些微生物群广泛存在肠道上皮和粘膜细胞表面，对维持机体健康起着非常重要的作用。如果正常的共生微生物群（肠道菌群）的生态平衡发生紊乱，将严重影响人体健康，引发风湿性关节炎、炎症性肠病、多发性硬化症及糖尿病等多种疾病。除了能抵御有害病菌造成的物理及化学的伤害，肠道菌群在维持免疫功能(Th17，Treg及固有淋巴细胞)方面也发挥着重要的作用。
肠道免疫系统能区分共生菌和病原菌，对共生菌产生免疫耐受，而对病原菌及其他抗原物质产生免疫反应。Th17细胞是能产生IL-17的CD4+T淋巴细胞亚群，Th17的产生依赖于肠道共生菌的存在，并成为肠道免疫屏障的重要组成部分。它的适量存在有助于维持肠道免疫功能，而Th17的过度诱导则会导致肠道免疫功能破坏。此外，在肠道免疫系统中对共生菌耐受的CD4+CD25+Treg细胞及其产生的一致性细胞因子IL-10和TGF-β也发挥着重要作用，Th17细胞的分化发育又与Treg细胞分化发育呈抑制性关系。因此，Th17和Treg细胞是连接着肠道菌群和肠道免疫功能的关键细胞亚群。
产品信息
肠道免疫系统能区分共生菌和病原菌，对共生菌产生免疫耐受，而对病原菌及其他抗原物质产生免疫反应。Th17细胞是能产生IL-17的CD4+T淋巴细胞亚群，Th17的产生依赖于肠道共生菌的存在，并成为肠道免疫屏障的重要组成部分。它的适量存在有助于维持肠道免疫功能，而Th17的过度诱导则会导致肠道免疫功能破坏。此外，在肠道免疫系统中对共生菌耐受的CD4+CD25+Treg细胞及其产生的一致性细胞因子IL-10和TGF-β也发挥着重要作用，Th17细胞的分化发育又与Treg细胞分化发育呈抑制性关系。因此，Th17和Treg细胞是连接着肠道菌群和肠道免疫功能的关键细胞亚群。
产品信息
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产品名称
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产品编号
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克隆号
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应用
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Anti-Mouse AHR Alexa Fluor® 488
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53-5925
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4MEJJ
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FC
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Anti-Mouse AHR eFluor® 660
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50-5925
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4MEJJ
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FC
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Anti-Mouse AHR PE
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12-5925
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4MEJJ
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FC
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Anti-Human AHR eFluor® 660
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50-9854
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FF3399
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FC
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Anti-Human AHR PE
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12-9854
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FF3399
|
FC
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Anti-Human AHR PerCP-eFluor® 710
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46-9854
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FF3399
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FC
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Anti-Human AHR Purified
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14-9854
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FF3399
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FC, ICC, IHC, WB
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Anti-Mouse Aiolos eFluor® 660
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50-5789
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8B2
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FC
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Anti-Mouse Aiolos PE
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12-5789
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8B2
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FC
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Anti-Mouse Aiolos Purified
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14-5789
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8B2
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WB
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Anti-Human Foxp3 PE-Cyanine7
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25-4776
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PCH101
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FC
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Anti-Human/Mouse c-Maf eFluor® 660
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50-9855
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sym0F1
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FC
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Anti-Human/Mouse c-Maf PerCP-eFluor® 710
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46-9855
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sym0F1
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FC
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Anti-Human CCL5 (RANTES) eFluor® 660
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50-9905
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VL1
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FC
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Anti-Mouse CD4 Alexa Fluor® 488
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53-0041
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GK1.5
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FC
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Anti-Mouse CD4 APC
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17-0041
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GK1.5
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FC
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Anti-Mouse CD4 APC-eFluor® 780
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47-0041
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GK1.5
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FC
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Anti-Mouse CD4 Biotin
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13-0041
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GK1.5
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FC
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Anti-Mouse CD4 Cyanine5
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19-0041
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GK1.5
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FC
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Anti-Mouse CD4 eFluor® 450
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48-0041
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GK1.5
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FC
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Anti-Mouse CD4 eFluor® 605NC
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93-0041
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GK1.5
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FC
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Anti-Mouse CD4 eFluor® 650NC
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95-0041
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GK1.5
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FC
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Anti-Mouse CD4 eFluor® 660
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50-0041
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GK1.5
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FC
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Anti-Mouse CD4 FITC
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11-0041
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GK1.5
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FC
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Anti-Mouse CD4 Functional Grade Purified
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16-0041
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GK1.5
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FC, FA
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Anti-Mouse CD4 PE
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12-0041
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GK1.5
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FC
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Anti-Mouse CD4 PE-Cyanine5
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15-0041
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GK1.5
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FC
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Anti-Mouse CD4 PE-Cyanine7
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25-0041
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GK1.5
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FC
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Anti-Mouse CD4 PerCP-eFluor® 710
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46-0041
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GK1.5
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FC
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Anti-Mouse CD4 Purified
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14-0041
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GK1.5
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FC, IHC, IP
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Anti-Human CD4 Alexa Fluor® 488
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53-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 APC
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17-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 APC-eFluor® 780
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47-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 Biotin
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13-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 eFluor® 450
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48-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 eFluor® 605NC
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93-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 eFluor® 660
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50-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 FITC
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11-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 Functional Grade Purified
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16-0048
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OKT4 (OKT-4)
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FC, IP
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Anti-Human CD4 PE
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12-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 PerCP-Cyanine5.5
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45-0048
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OKT4 (OKT-4)
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FC
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Anti-Human CD4 Purified
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14-0048
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OKT4 (OKT-4)
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FC, IP
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Anti-Rat CD4 APC
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17-0040
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OX35
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FC
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Anti-Rat CD4 FITC
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11-0040
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OX35
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FC
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Anti-Rat CD4 PE
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12-0040
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OX35
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FC
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Anti-Rat CD4 PerCP-eFluor® 710
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46-0040
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OX35
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FC
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Anti-Rat CD4 Purified
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14-0040
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OX35
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FC, IHC
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Anti-Mouse CD4 Biotin
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13-0043
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RM4-4
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FC
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Anti-Mouse CD4 FITC
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11-0043
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RM4-4
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FC
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Anti-Human CD25 Alexa Fluor® 488
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53-0259
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BC96
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FC
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Anti-Human CD25 APC
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17-0259
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BC96
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FC
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Anti-Human CD25 APC-eFluor® 780
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47-0259
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BC96
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FC
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Anti-Human CD25 Biotin
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13-0259
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BC96
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FC
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Anti-Human CD25 eFluor® 450
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48-0259
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BC96
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FC
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Anti-Human CD25 PE
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12-0259
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BC96
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FC
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Anti-Human CD25 PE-Cyanine5
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15-0259
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BC96
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FC
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Anti-Human CD25 PE-Cyanine7
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25-0259
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BC96
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FC
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Anti-Human CD25 PerCP-Cyanine5.5
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45-0259
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BC96
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FC
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Anti-Human CD25 Purified
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14-0259
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BC96
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FC
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Anti-Human/Non-Human Primate CD25 APC
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17-0257
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CD25-4E3
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FC
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Anti-Human/Non-Human Primate CD25 eFluor® 450
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48-0257
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CD25-4E3
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FC
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Anti-Human/Non-Human Primate CD25 PE
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12-0257
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CD25-4E3
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FC
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Anti-Human/Non-Human Primate CD25 PE-Cyanine7
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25-0257
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CD25-4E3
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FC
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Anti-Human/Non-Human Primate CD25 PE-eFluor® 610
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61-0257
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CD25-4E3
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FC
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Anti-Human/Non-Human Primate CD25 PerCP-eFluor® 710
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46-0257
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CD25-4E3
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FC
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Anti-Mouse CD25 Alexa Fluor® 488
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53-0253
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eBio3C7 (3C7)
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FC
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Anti-Mouse CD25 eFluor® 450
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48-0253
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eBio3C7 (3C7)
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FC
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Anti-Mouse CD25 Functional Grade Purified
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16-0253
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eBio3C7 (3C7)
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FC, FA
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Anti-Mouse CD25 Alexa Fluor® 488
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53-0252
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eBio7D4 (7D4)
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FC
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Anti-Mouse CD25 Biotin
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13-0252
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eBio7D4 (7D4)
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FC
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Anti-Mouse CD25 eFluor® 660
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50-0252
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eBio7D4 (7D4)
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FC
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Anti-Rat CD25 APC
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17-0390
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OX39
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FC, IHC
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Anti-Rat CD25 Biotin
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13-0390
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OX39
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FC, IHC
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Anti-Rat CD25 Functional Grade Purified
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16-0390
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OX39
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FC, FA
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Anti-Rat CD25 PE
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12-0390
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OX39
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FC
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Anti-Rat CD25 PerCP-eFluor® 710
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46-0390
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OX39
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FC
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Anti-Rat CD25 Purified
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14-0390
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OX39
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FC, IHC
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Anti-Canine CD25 eFluor® 660
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50-0250
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P4A10
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FC
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Anti-Canine CD25 FITC
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11-0250
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P4A10
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FC
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Anti-Canine CD25 PE
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12-0250
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P4A10
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FC
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Anti-Mouse CD25 Alexa Fluor® 488
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53-0251
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PC61.5
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FC
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Anti-Mouse CD25 PE-Cyanine5.5
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35-0251
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PC61.5
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FC
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Anti-Mouse CD25 Alexa Fluor® 700
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56-0251
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PC61.5
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FC
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Anti-Mouse CD25 APC
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17-0251
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PC61.5
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FC
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Anti-Mouse CD25 APC-eFluor® 780
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47-0251
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PC61.5
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FC
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Anti-Helios eFluor® 450
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48-9883
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22F6
|
FC
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Anti-Mouse Dectin-1 PE
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12-5859
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bg1fpj
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FC
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Anti-Mouse ST2 (IL-33R) PerCP-eFluor® 710
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46-9335
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RMST2-2
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FC
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Anti-Human CD294 (CRTH2) eFluor® 660
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50-2949
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BM16
|
FC
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Anti-Human AHR eFluor® 660
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50-9854
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FF3399
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FC
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Human IL-23 Recombinant Protein Carrier-Free
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34-8239
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FA
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Anti-Human IL-17AF eFluor® 450
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48-9179
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20LJS09
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FC
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参考文献
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1. Mathis D., Benoist C. (2011). Microbiota and autoimmune disease: the hosted self. Cell Host Microbe. 10, 297–30. 2. Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Mu¨ ller, W., Sparwasser, T., Forster, R., and Pabst, O. (2011). Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34, 237–246. 3. Littman D.R., Pamer E.G. (2011). Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses. Cell Host Microbe. 10, 311-23. 4. Qin J, Li R, Raes J, Arumugam M, et. al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature. (7285):59-65. 5. Ivanov I. I., Littman D. R. (2010). Segmented filamentous bacteria take the stage. Mucosal Immunol. 3, 209–212. doi: 10.1038/mi.2010.3. 6. Wu, H.J., Ivanov, I.I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D.R., Benoist, C., and Mathis, D. (2010). Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells . Immunity 32, 815–827. 7. Gaboriau-Routhiau, V., Rakotobe, S., Le´cuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009). The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677–689. |
