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Autophagy in human health and diseases
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Autophagy contributes to basal physiological homeostasis by regenerating metabolic precursors and clearing subcellular debris. Deregulation of this process has been implicated in many diseases, including cancer, metabolic and neuro degenerative disorders, and cardiovascular and pulmonary diseases. Shown above, the diagram reports the publication trends for the study of autophagy. However, clinical targeting of autophagy in human diseases is limited due to an obscure of how autophagy contributes to pathogenesis. Exploration of the mechanisms underlying this autophagy process may lead to the identification of new targets for clinical utility.
Please find the list below for a collection of autophagy molecules associated with human diseases.
For a complete catalogs of autophagy antibodies from GeneTex, visit our website at
http://www.genetex.com/Web/News/Autophagy-332
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Gene
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Antibody
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Association
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BECN1
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Breast, ovarian, and prostate cancers
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UVRAG
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Colon cancers
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ATG1
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Major autophagy initiator
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ATG9
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Assists in autophagosomal assembly
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ATG5
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Systemic lupus erythematosus, asthma, and lung dysfunction
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ATG16L1
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Chrohn's disease
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NOD2
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Chrohn's disease, and mycobacterium leprae infection
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IRGM
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Chrohn's disease, and M. tuberculosis infection
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LAMP2
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Danon's cardiomyopathy
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PARK2
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Parkinson's disease, colon, lung and breast cancers
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SQSTM1
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Paget's disease
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SMURF1
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Ulcerative colitis
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