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InvivoGen公司可提供多种佐剂, 并且InvivoGen的佐剂均为疫苗级别的,确保无菌和无内毒素。


佐剂的分类---常用的佐剂可分为以下4类
● 无机佐剂:如氢氧化铝,明矾等;

● 有机佐剂:微生物及其产物如分枝杆菌(结核杆菌、卡介苗)、短小杆菌、百日咳杆菌、内毒素、细菌提取物(胞壁酰二肽)等;
● 合成佐剂:如人工合成的双链多聚核苷酸(双链多聚腺苷酸、尿苷酸)、左旋咪唑、异丙肌苷等;
● 油剂:如弗氏佐剂、花生油乳化佐剂、矿物油、植物油等。
● 其中,弗氏佐剂是目前动物实验中最常用的一种佐剂。

明矾和乳剂
明矾和乳剂,通过将抗原固定在注射部位,让其缓慢释放从而达到持续刺激免疫系统的作用。这些佐剂可使抗原在注射部位长久存在,增强抗原递呈细胞(APCs)的募集和活化。明矾可与抗原结合形成多分子聚合物,从而促进其被APCs的摄取。

明矾(Alum )
用于人类疫苗接种最常用的一种佐剂,存在于多种疫苗中,包括白喉-百日咳-破伤风三联苗、人乳头瘤病毒疫苗和肝炎病毒疫苗。明矾可引起强烈的Th2细胞应答,但是对于需要Th1细胞调节的免疫应答来清除的病原体是无效的。

完全弗氏佐剂(Complete Freund's Adjuvant,CFA)
由热灭活的结核分支杆菌、石蜡油和羊毛脂混合而成, 具有TLR2, TLR4, and TLR9的配体,主要引起Th1细胞免疫应答;而不完全弗氏佐剂(Freund’s Incomplete Adjuvant ,IFA)和CFA相比,缺少结核分枝杆菌这一成分,主要诱导Th2细胞免疫应答。在大多数实验中,CFA被用于初次免疫,IFA被用于后续的免疫中。

AddaVax™
一种基于鲨烯的水包油纳米乳剂,其构成与诺华专利佐剂MF59®相似。主要通过募集和活化APC,刺激巨噬细胞和粒细胞产生细胞因子和趋化因子发挥作用。

 
 产品名称  产品描述  品牌
 AddaVax™  Squalene-Oil-in-water Th2 response   InvivoGen
 Alhydrogel® 2%  Aluminium hydroxide gel Th2 Response  InvivoGen
 CFA  Complete Freund’s Adjuvant Th1 response  InvivoGen
 IFA  Incomplete Freund's adjuvant Th2 response  InvivoGen




 产品货号  产品名称  品牌
 7015  Complete Freund's Adjuvant, 3 mg/ml  Chondrex
 7001  Complete Freund's Adjuvant, 4 mg/ml  Chondrex
 7002  Incomplete Freund's Adjuvant  Chondrex

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