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Y27632是一种具有细胞渗透性的ROCK抑制剂,能选择性的抑制ROCK1(p160ROCK)和ROCK2。

 

CAS: 129830-38-2  

纯度:>98%

保存:-20 °C避光保存。 

 

货号

产品名称 

规格

纯度

品牌

ALX-270-333-M025

Y-27632 . dihydrochloride

25 mg

>98%

ENZO(美国)

ALX-270-333-M005

Y-27632 . dihydrochloride

5 mg

>98%

ENZO(美国)

ALX-270-333-M001

Y-27632 . dihydrochloride

1 mg

>98%

ENZO(美国)

 

 

文献引用

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1. The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling: 

      A.C. Perey, et al.; Cell Immunol. 293, 80 (2015), Application(s): Cell Culture, Abstract;

2. Dissecting the roles of ROCK isoforms in stress-induced cell detachment. : J. Shi, et al. ; Cell Cycle 12, 1492,1500 (2013),Abstract;

3. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment: J. Shi, et al.; Cell Death Dis. 4, e483 (2013),Abstract; Full Text;

4. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. : FA. Suprynowicz, et al. ; PNAS 109, 20035,20040 (2012), 

     Abstract;

5. ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells : X. Liu, et al.; Am. J. Pathol. 180, 599,607 (2012),

     Abstract;

6. Use of reprogrammed cells to identify therapy for respiratory papillomatosis. : H. Yuan, et al. ; N Engl J Med 367, 1220,1227 (2012), Abstract;

7. Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes 

     involved in tumor initiation and progression: C. Spencer, et al.; Cancer Genom. Proteom. 8, 77 (2011), Abstract;

8. Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia. : AJ. Ziino, 

     et al.; Pediatr Res. 67, 177,82 (2010), Abstract;

9. The proline-rich region of HIV-1 Nef affects CXCR4-mediated chemotaxis in Jurkat T cells: C.M. Lee, et al.; Viral Immunol. 21, 347 (2008), Abstract;

10. A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release: L. Fernandes, et al.; Eur. J. Pharmacol. 550, 

     155 (2006), Abstract;

11. Molecular characterization of the effects of Y-27632: H. Darenfed, et al.; Cell Motil. Cytoskeleton (2006), Abstract;

12. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice: K. Buyukafsar, et al.; Eur. J. Pharmacol. 541, 49 (2006),Abstract;

13. Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632: H. Yamaguchi, et al.; J. Biochem (Tokyo) 140, 305 (2006), Abstract;

14. Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal failure in rats: K. Teraishi, et al.; 

       Eur. J. Pharmacol. 505, 205 (2004), Abstract;

15. Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells: M. Aihara, et al.; Int. Immunopharmacol. 

      3, 1619 (2003), Abstract;

16. Inhibition of high K+-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle: possible involvement of ROCKs in a signal 

       transduction pathway: K. Sakamoto, et al.; J. Pharmacol. Sci. 92, 56 (2003), Abstract;

17. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity: C. Breitenlechner, et al.; 

       Structure 11, 1595 (2003), Abstract;

18. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells: R.W. Rees, et al.; J. Urol. 

       170, 2517 (2003), Abstract;

19. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway: K. Chitaley, et al.; Nat. Med. 7, 119 (2001),

       Abstract;

20. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632: M. Takamura, 

      et al.; Hepatology 33, 577 (2001), Abstract;

21. A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth: H. Iwamoto, et al.; J. Hepatol. 32, 762 (2000), Abstract;

22. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases: T. Ishizaki, et al.; Mol. Pharmacol. 57, 976 (2000), Abstract;

23. Specificity and mechanism of action of some commonly used protein kinase inhibitors: S.P. Davies, et al.; Biochem. J. 351, 95 (2000), Abstract; Full Text

24. The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes: A. Ka

       waguchi, et al.; Eur. J. Pharmacol. 403, 203 (2000), Abstract;

25. Use and properties of ROCK-specific inhibitor Y-27632: S. Narumiya, et al.; Meth. Enzymol. 325, 273 (2000), Abstract;

26. Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase: F. Ima

       mura, et al.; Jpn. J. Cancer Res. 91, 811 (2000), Abstract;

27. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase: M. Maekawa, et al.; Science 285, 895 (1999), Abstract;

28. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells: M. Hirose, et al.; 

      J. Cell Biol. 141, 1625 (1998), Abstract;

29. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension: M. Uehata, et al.; Nature389, 990 (1997), Abstract;

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