GeneTex 2015年9月免费抗体清单

DNA甲基化是抑制基因转录的典型表观遗传修饰，其在癌变等病理过程上也扮演重要角色。潜在的调节机制为：哺乳动物5-甲基胞嘧啶双加氧酶家族3个成员（Ten Eleven Translocation（TET）：人TET1，TET2和TET3），氧化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶(5-hmC)， 接着转变为5-甲酰胞嘧啶(5-fC)及5-胞嘧啶羧基(5-caC)，这系列的修饰被认为是活化DNA去甲基化通路，从而重朔由DNA甲基转移酶(DNMTs)建立的DNA甲基化。

GeneTex推出DNA甲基化与去甲基化相关蛋白的试用抗体，大部分抗体能用于IP/ChIP实验，欢迎试用并将您宝贵的意见反馈给我们。

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本月免费抗体清单

Introduction

DNA methylation typically acts to suppress gene transcription, and is associated with several key pathophysiological processes, including carcinogenesis. The underlying mechanisms are regulated mainly by three mammalian 5-methylcytosine (5-mC) dioxygenases (Ten Eleven Translocation (TET); TET1, TET2, and TET3 in humans), which convert 5-mC to 5-hydroxymethylcytosine (5-hmC) and subsequently to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). This series of modifications is thought to represent one pathway to active DNA demethylation, thereby reshaping the methylated DNA landscape established by DNA methyltransferases (DNMTs).

Cat. No.	Product Name	Reactivity	Host & Clonality	Application
GTX629448	5-Methylcytosine / 5-mC antibody [GT4111]	Other	Ms mAb	Dot, IHC-P, IHC-Wm, MeDIP
GTX128455	5-MethylCytosine / 5-mC antibody	Other	Rb pAb	Dot
GTX629765	5-HydroxymethylCytosine / 5-hmC antibody [GT13612]	Other	Ms mAb	Dot, IHC-P, MeDIP
GTX128454	5-HydroxymethylCytosine / 5-hmC antibody	Other	Rb pAb	Dot
GTX627420	TET1 antibody [GT1462]	Hu	Ms mAb	ICC/IF, IHC-P, IP, WB, ChIP assay
GTX124205	TET2 antibody [N2-2], N-term	Hu	Rb pAb	ICC/IF, IHC-P, IP, WB, ChIP assay
GTX121453	TET3 antibody [C3], C-term	Hu, Ms, Xl, Bov	Rb pAb	ICC/IF, IHC-P, IP, WB, IHC-Wm
GTX116011	DNMT1 antibody [N1], N-term	Hu	Rb pAb	ICC/IF, IHC-P, IP, WB, ChIP assay
GTX129125	DNMT3A antibody	Hu, Ms	Rb pAb	ICC/IF, IHC-P, IP, WB
GTX129127	DNMT3B antibody	Hu	Rb pAb	IHC-P, IP, WB
GTX110473	TDG antibody	Hu	Rb pAb	ICC/IF, WB
GTX129153	G9a antibody	Hu	Rb pAb	ICC/IF, IHC-P, IP, WB
GTX113963	UHRF1 antibody	Hu	Rb pAb	ICC/IF, IHC-P, IP, WB, ChIP assay
GTX100513	HDAC1 antibody	Hu, Ms	Rb pAb	ICC/IF, IHC-P, IP, WB, ChIP assay
GTX100539	PCNA antibody	Hu, Ms, Rat	Rb pAb	ICC/IF, IHC, IHC-P, WB
GTX129035	SETD1A antibody	Hu	Rb pAb	WB
GTX115305	SETDB1 antibody [N1], N-term	Hu, Ms	Rb pAb	IP, WB, ChIP assay
GTX112263	SUV39H1 antibody [N3C3]	Hu, Ms, Mk	Rb pAb	ICC/IF, IHC-P, IP, WB
GTX101310	ATRX antibody [C3], C-term	Hu, Ms	Rb pAb	ICC/IF, IHC-P, IP, WB
GTX102226	KAP1 antibody [N3C2], Internal	Hu, Ms	Rb pAb	ICC/IF, IHC-P, IP, WB, ChIP assay

活动细则:

1. 本活动仅适用中国，并不得与其他优惠并用

  2. 活动日期自2015年9月1日至9月30日
  3. 每人限索取2管，且不得为同一货号
  4. GeneTex保有活动解释权