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当前位置：首页 > 品牌资讯 >免疫疗法无效的可能原因-β-catenin

虽然使用新的免疫治疗方法(例如，利用抗CTLA-4，PD-1和PD-L1的抗体)来对抗恶性肿瘤令人振奋，但你知道实际上只有一部分的患者有临床反应吗?研究表示，主要的问题在于CD8+T细胞是否浸润到肿瘤微环境中，发挥T细胞抗肿瘤反应。在Nature Letter文章中，研究黑色素瘤的Spranger等人发现Wnt/β-catenin信号通路被激活，会削弱T细胞对肿瘤的反应，也就是抑制 beta-catenin

可以提高免疫治疗的效果。

美国GeneTex提供WNT/β-catenin通路的专一性抗体。，快来研究相关标的是否还有其他惊人的作用吧~

Reference:

1. Nature. 2015 Jul 9;523(7559):231-5

2. 更多资讯链结

http://crm.itpison.com/Var/Elite/9c222ff2-6b03-4db3-9768-d35bdc97e9fc/BACKUP/HTML/506082716.htm

 

 

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