上皮细胞间质转型（epithelial-mesenchymal transitions,EMT）是上皮细胞由紧密固定排列转换为排列松散可移动的过程。EMT不仅在胚胎发育过程中促进细胞形态改变，也可促进肿瘤细胞侵袭和转移的能力。目前已经证实, 当癌细胞进行EMT转换时，许多的通路（如TGF beta, Wnt/ beta-catenin, integrins, and Notch通路）可通过细胞骨架重组与活化E-cadherin抑制物诱导EMT发生。因此，抑制EMT也被视为抑制肿瘤转移的策略之一。
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| Introduction |
Epithelial-mesenchymal transition phenotype of looselyadherent and motile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with Ecadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways (TGF beta, Wnt/ betacatenin, integrins, and Notch etc.) have been reported to induce EMT via cytoskeleton rearrangement and activation of E-cadherin repressors. |
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| CatNo | ProductName | Application | Citation | Reactivity | Validation |
| GTX629702 | alpha Smooth Muscle Actin antibody [GT445] | Y | |||
| GTX628472 | CD44 antibody [GT981] | Y | |||
| GTX112731 | COL1A1 antibody [N1N2], N-term | Y | |||
| GTX100616 | c-Yes antibody | ||||
| GTX124178 | E-Cadherin antibody [N3C2], Internal | Y | KD | ||
| GTX628887 | EGFR antibody [GT133] | Y | |||
| GTX112794 | Fibronectin antibody [N1N2], N-term | Y | |||
| GTX111192 | GSK3 beta antibody [C1C3] | Y | KD | ||
| GTX127309 | HIF1 alpha antibody | Y | KD | ||
| GTX130705 | Integrin alpha 5 antibody | ||||
| GTX100565 | Integrin alpha 6 antibody [N3C2], Internal | Y | |||
| GTX128839 | Integrin beta 1 / CD29 antibody | Y | |||
| GTX100534 | MMP1 antibody | Y | |||
| GTX104577 | MMP2 antibody | Y | |||
| GTX127345 | N-Cadherin antibody | Y | |||
| GTX108247 | ROCK2 antibody [N3C1], Internal | Y | KD | ||
| GTX132369 | Src antibody | Y | |||
| GTX110630 | TGF beta 1 antibody | Y | |||
| GTX127310 | Twist1/2 antibody | Y | |||
| GTX112661 | Vimentin antibody | Y | KD |
Human, Mouse, Rat,
Zebrafish
CatNo
ProductName
Application
Reactivity
Validation
GTX132812
AKT1 (phospho Ser129) antibody
WB
Human
GTX132417
AKT3 (E17K Mutant Specific) antibody
WB
Human
GTX633544
ATP6V1A antibody [GT1561]
WB
Human
GTX132611
beta Catenin (phospho Ser675) antibody
WB
Human
GTX132331
Caspase 9 (cleaved Asp330) antibody
WB
Human
GTX628143
Citrate synthetase antibody [GT1761]
ICC/IF, IHC-P, WB
KD
GTX132816
CREB (phospho Ser133) antibody
WB
Human
GTX129318
DLX4 antibody
WB
Human
GTX132810
EGFR (phospho Tyr1068) antibody
WB
Human
GTX633631
eIF3H / EIF3S3 antibody [GT35512]
ICC/IF, WB
Human
GTX129252
FOXP1 antibody
WB
Human
GTX633675
Gelsolin antibody
WB
Human
GTX633625
IDE antibody [GT286]
WB
Human
GTX133076
IDH1 antibody
WB
Human
GTX132808
IRE1 (phospho Ser724) antibody
WB
Human
GTX132655
LAMP2A antibody
WB
Human
GTX132580
mLST8 / GBL antibody
WB
Human
GTX131085
Neuroligin 3 antibody
WB
Human, Mouse, Rat
GTX133212
Nkx2.2 antibody
WB
Mouse, Rat
GTX132575
Optineurin antibody
ICC/IF, WB
Human
GTX132574
Park7 / DJ-1 antibody
IHC-P, WB
Human, Rat
GTX633633
Paxillin (phospho Tyr118) antibody [GT712]
ICC/IF, WB
Human
GTX131508
Raptor antibody
WB
Human
GTX133211
SAP102 antibody
WB
Mouse, Rat
GTX131028
SNAP29 antibody
WB
Human
GTX129802
SNRPB2 antibody
WB
Human
GTX132660
ULK1 (phospho Ser555) antibody
WB
Human
GTX132786
VAV1 (phospho Tyr174) antibody
WB
Human
GTX128233
WISP2 antibody
WB
Human
GTX129151
YAP1 antibody
ICC/IF, IHC-P, IP, WB
Human
