糖尿病是一种慢性病，当胰腺产生不了足够的胰岛素或者人体无法有效地利用所产生的胰岛素时，就会出现糖尿病。全世界有3.47亿人患有糖尿病。2004年，估计有340万人死于空腹高血糖带来的后果。2010年的估计死亡数字与之相似。世卫组织预测，2030年糖尿病将成为第七位主要死因。目前我国的糖尿病的发病率呈升高趋势，但发病机理尚未完全阐明，在预防和治疗方面仍不完善，建立理想的动物模型对进一步研究糖尿病具有重要的意义。
迄今为止，已建立了多种建立糖尿病动物模型的方法，主要有：(1) 手术切除胰腺；(2) 化学药物诱导；(3) 自发性DM；(4) 转基因动物等。其中化合药物诱导法中采用链脲佐菌素注射造模因其对组织毒性较小，动物存活率高，所以是目前国内外使用较多的一种制备糖尿病动物模型的方法。
链脲佐菌素（英语：Streptozotocin或Streptozocin，简称STZ，又名链佐星、链脲霉素）是一种由链球菌产生的，对哺乳动物胰脏中产生胰岛素的胰岛B细胞有着特异毒性的天然化合物。它能破坏胰岛B细胞，大剂量可诱导I型糖尿病，小剂量反复注射可致II型糖尿病。
Enzo Lifesciences目前可提供以下三种规格链脲佐菌素供广大研究者选用。
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品牌
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产品编号
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产品名称
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规格
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ENZO
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ALX-380-010-G001
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Streptozotocin
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1 x 1 g
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ENZO
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ALX-380-010-5100
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Streptozotocin
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5 x 100 mg
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ENZO
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ALX-380-010-M100
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Streptozotocin
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1 x 100 mg
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产品文献引用
1. Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007).
2. Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review).
3. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas: T. Szkudelski; Physiol. Res. 50, 537 (2001), (Review).
4. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets: F.J. Bedoya, et al.; Experientia 52, 344 (1996).
5. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage: K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler 376, 179 (1995).
6. Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994).
7. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets: J. Turk, et al.; BBRC 197, 1458 (1993).
8. NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993).
9. Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation: G. Thomas & P. Ramwell; Eur. J. Pharmacol. 161, 279 (1989).
10. Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice: H. Kolb; Diabetes Metab. Rev. 3, 751 (1987).
11. Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981).
12. The structure of streptozotocin: R.R. Herr, et al.; JACS 89, 4808 (1967).
13. Studies on the diabetogenic action of streptozotocin: N. Rakieten, et al.; Cancer Chemother. Rep. 29, 91 (1963).
1. Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007).
2. Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review).
3. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas: T. Szkudelski; Physiol. Res. 50, 537 (2001), (Review).
4. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets: F.J. Bedoya, et al.; Experientia 52, 344 (1996).
5. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage: K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler 376, 179 (1995).
6. Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994).
7. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets: J. Turk, et al.; BBRC 197, 1458 (1993).
8. NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993).
9. Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation: G. Thomas & P. Ramwell; Eur. J. Pharmacol. 161, 279 (1989).
10. Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice: H. Kolb; Diabetes Metab. Rev. 3, 751 (1987).
11. Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981).
12. The structure of streptozotocin: R.R. Herr, et al.; JACS 89, 4808 (1967).
13. Studies on the diabetogenic action of streptozotocin: N. Rakieten, et al.; Cancer Chemother. Rep. 29, 91 (1963).
