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Product Information: Human Topoisomerase II Beta


Storage
- Temperature: Store at -80°C for long-term storage. Avoid repeated freeze-thaw cycles.
- Shelf Life: Stable for up to 12 months when stored properly.
- Handling: Thaw on ice before use. Once thawed, aliquot to avoid repeated freeze-thaw cycles.


Product Description
Human Topoisomerase II Beta is a critical enzyme involved in DNA replication, transcription, and chromosome segregation. It facilitates the relaxation of supercoiled DNA, allowing essential cellular processes to occur efficiently. This recombinant enzyme is expressed in a highly purified form, ensuring high activity and reliability in experimental applications.


Key Features
- High Purity: Greater than 95% purity, verified by SDS-PAGE.
- Activity: Demonstrates robust catalytic activity for efficient DNA decatenation.
- Recombinant Source: Produced in a controlled environment to ensure consistent quality.
- Versatility: Suitable for a variety of molecular biology applications.


What's Included
- Human Topoisomerase II Beta enzyme: Provided in a buffered solution to maintain stability.
- User Manual: Detailed instructions for use and storage.
- Safety Data Sheet (SDS): Information on handling and potential hazards.


Applications
- DNA Replication Studies: Investigate the role of topoisomerase II beta in DNA synthesis.
- Transcription Research: Explore how this enzyme affects gene expression regulation.
- Chromosome Segregation Analysis: Use in studies related to mitosis and meiosis.
- Drug Discovery: Evaluate potential inhibitors targeting topoisomerase activity.
- Cancer Research: Understand the implications of topoisomerase II beta in tumor development and progression.

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This product is indispensable for researchers focused on understanding the complexities of DNA dynamics and chromosome behavior. By following the storage guidelines and utilizing the features outlined, you can maximize the enzyme's effectiveness in your experimental endeavors.