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Filipin III Product Information


Storage
- Temperature: Store Filipin III at -20°C to ensure stability and maintain its efficacy.
- Protection: Keep the product in a dark, airtight container to protect it from light and moisture.
- Shelf Life: When stored correctly, Filipin III remains stable for up to two years.


Product Description
Filipin III is a polyene macrolide antibiotic derived from Streptomyces filipinensis. It is extensively used in biochemical research due to its ability to bind sterols, particularly cholesterol, within cell membranes. This binding forms a complex that disrupts membrane structure and function, making Filipin III a valuable tool for studying sterol-related processes.


Key Features
- Sterol Binding: Highly effective in binding to sterols, particularly cholesterol, enabling researchers to study sterol distribution and dynamics within cell membranes.
- Fluorescent Properties: Filipin III exhibits intrinsic fluorescence, making it useful for visualizing sterol distribution in cells under a fluorescence microscope.
- Research Grade: Optimized for laboratory research purposes with high purity to ensure reliable and reproducible results.


What's Included
- Filipin III: Provided in a powdered form, typically in quantities suitable for research applications (e.g., 1 mg, 5 mg).
- Documentation: Includes a certificate of analysis and safety data sheet to ensure safe handling and application.
- Usage Instructions: Detailed guidelines on how to dissolve and use the product effectively in experimental setups.


Applications
- Cell Membrane Studies: Utilized to investigate cell membrane composition, fluidity, and structure by binding to cholesterol and disrupting lipid organization.
- Sterol Research: Essential for studies related to sterol metabolism, transport, and distribution within various biological systems.
- Disease Mechanism Exploration: Helps in understanding diseases linked to cholesterol dysregulation, such as Niemann-Pick disease and atherosclerosis.
- Fluorescent Imaging: Employed in fluorescence microscopy to visualize and quantify sterol presence and movement within live cells.

Filipin III is a versatile and indispensable tool in biochemical and cell biology research, providing insights into sterol function and membrane dynamics. Proper storage and handling ensure its effectiveness and longevity in research applications.