Certainly! Here's an improved and supplemented product information sheet for DOTA-NHS-ester:

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Product Name: DOTA-NHS-ester

Storage:
- Store at -20°C to maintain stability.
- Keep the product in a dry environment, protected from light.
- Once opened, use promptly to prevent degradation. If necessary, reseal tightly and store at recommended conditions.

Product Description:
DOTA-NHS-ester is a bifunctional chelating agent widely used in the field of radiolabeling. It features a reactive N-hydroxysuccinimide (NHS) ester group, which facilitates the conjugation of the chelator to amine groups on biomolecules, such as proteins and peptides. The DOTA moiety is known for its high affinity and stability with a variety of metal ions, making it ideal for applications requiring metal complexation.

Key Features:
- High Stability: DOTA-NHS-ester forms stable complexes with a range of metal ions, especially lanthanides and transition metals.
- Reactive NHS Ester: Allows for efficient conjugation to primary amines under mild conditions.
- Versatile Applications: Suitable for radiolabeling, metal chelation, and enhancing the imaging or therapeutic capabilities of biological molecules.
- Purity: Offered in high purity for optimal performance in sensitive applications.

What's Included:
- DOTA-NHS-ester, supplied in a sealed vial.
- Product datasheet with handling instructions and safety data.
- Certificate of analysis verifying product integrity and purity.

Applications:
- Radiolabeling: Used in the preparation of radiolabeled compounds for diagnostic imaging (e.g., PET, SPECT) and therapeutic applications.
- Metal Chelation: Ideal for complexation with metals such as gadolinium, indium, and yttrium for enhanced imaging contrast or targeted therapy.
- Bioconjugation: Facilitates the attachment of metals to proteins, peptides, and other biomolecules for research and clinical applications.
- Drug Development: Utilized in the design of novel therapeutics that require precision targeting and delivery.

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This enhanced product information provides a comprehensive overview for potential users of DOTA-NHS-ester, focusing on its storage, description, features, contents, and applications.