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Product Name:
ProQinase™ PDGFRalpha D842V

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Storage:
- Temperature: Store at -80°C for optimal stability. Avoid repeated freeze-thaw cycles to maintain enzyme integrity.
- Conditions: Ensure the product is stored in a dry and dark environment to prevent degradation. Use sealed containers to protect from moisture and light exposure.

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Product Description:
ProQinase™ PDGFRalpha D842V is a recombinant enzyme featuring the D842V mutation, which is implicated in various oncogenic processes. This kinase is part of the platelet-derived growth factor receptor (PDGFR) family, playing a critical role in cell signaling pathways that govern growth and differentiation. The D842V mutation is known for its constitutive activation, leading to uncontrolled cellular proliferation, particularly in certain cancers.

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Key Features:
- High Purity: Produced using advanced recombinant technology to ensure high purity and activity.
- Mutational Specificity: Contains the clinically relevant D842V mutation, providing a vital tool for studying its biological effects.
- Activity: Demonstrates robust kinase activity, ideal for biochemical assays.
- Compatibility: Suitable for use in various assay formats, including ELISA and Western blotting.

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What's Included:
- ProQinase™ PDGFRalpha D842V enzyme: Supplied in a buffer solution optimized for stability and activity.
- User Manual/Protocol: Detailed instructions for handling and experimental procedures.
- Certificate of Analysis: Provides batch-specific information regarding enzyme activity, purity, and quality control results.

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Applications:
- Cancer Research: Investigate the role of PDGFRalpha D842V in tumorigenesis and potential therapeutic interventions.
- Drug Development: Screen inhibitors targeting the PDGFRalpha pathway, particularly for cancers driven by the D842V mutation.
- Biochemical Studies: Analyze kinase activity and downstream signaling effects in cellular models.
- Diagnostic Tool: Assist in the development of diagnostic assays for diseases associated with PDGFRalpha mutations.

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