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IdeS (70U/μl) Product Information


Storage
- Temperature: Store at -20°C.
- Conditions: Keep the product in a dry and dark environment to maintain stability.
- Shelf Life: Typically stable for up to 12 months when stored properly. Avoid repeated freeze-thaw cycles to ensure activity.


Product Description
IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes) is a cysteine protease derived from Streptococcus pyogenes. This enzyme specifically cleaves human IgG antibodies at the hinge region, producing F(ab')2 and Fc fragments. IdeS is utilized in various applications, including research involving antibody function and structure studies.


Key Features
- Specificity: Cleaves human IgG specifically at the hinge region.
- Efficiency: Rapid cleavage under optimal conditions, typically within minutes.
- Purity: High purity, recombinant enzyme ensuring consistent performance.
- Activity: High enzymatic activity at 70 units per microliter, allowing effective IgG cleavage.


What's Included
- IdeS Enzyme: 70U/μl in buffered solution.
- Buffer: Compatible buffer for enzymatic activity.
- Protocol: Detailed instructions for optimal use and cleavage efficiency.
- Safety Data Sheet (SDS): Documentation for safe handling and usage.


Applications
- Antibody Fragmentation: Generate F(ab')2 and Fc fragments for structural and functional studies.
- Preclinical Research: Investigate mechanisms of antibody-mediated diseases and therapeutic antibody development.
- Proteomics: Analyze antibody-antigen interactions and protein complexes.
- Biotechnological Processes: Enhance antibody purification and modification processes.

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This comprehensive product information should provide clarity and useful guidance for users handling IdeS in laboratory settings. Always consult the product's specific documentation and safety guidelines provided by the manufacturer for precise instructions and handling.