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ProQinase™ MEK1 K97M

Storage:
- Store at -80°C for long-term stability.
- Avoid repeated freeze-thaw cycles to maintain product integrity.
- Upon thawing, aliquot the product to prevent degradation and store aliquots at -20°C.

Product Description:
ProQinase™ MEK1 K97M is a mutated form of MEK1 (Mitogen-activated protein kinase kinase 1), specifically carrying the K97M mutation. This mutation renders the kinase inactive, making it an ideal tool for studies focused on kinase activity regulation, inhibitor screening, and signaling pathway analysis. MEK1 is part of the MAPK/ERK pathway, a critical signaling cascade involved in cell division, differentiation, and survival.

Key Features:
- Inhibition Profile: Contains the K97M mutation to render the kinase inactive, allowing for controlled experimental conditions.
- High Purity: Produced using rigorous purification processes to ensure high-quality protein suitable for biochemical assays.
- Reproducibility: Each batch is tested to confirm inactivity and consistency, ensuring reliable experimental results.
- Versatility: Applicable in various research settings including structural studies, pathway analysis, and inhibitor screening.

What's Included:
- ProQinase™ MEK1 K97M protein, supplied in a buffer optimized for stability.
- Certificate of Analysis detailing purity, concentration, and activity assay results.
- User guide with protocols for typical applications and storage instructions.
- Material Safety Data Sheet (MSDS) for safe handling practices.

Applications:
- Kinase Inhibitor Screening: Use as a control to verify inhibitor specificity for active MEK1 forms.
- Signal Transduction Studies: Investigate the downstream effects of MEK1 activity modulation within the MAPK/ERK pathway.
- Structural Biology: Analyze the structural implications of the K97M mutation on kinase conformation.
- Drug Discovery: Aid in the identification and characterization of novel therapeutic compounds targeting the kinase pathway.

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