Product Applications Read our PhotoHA-Soft Photocrosslinking Rheology White Paper here. Read our Methacrylated Extracellular Matrices eBrochure Here PhotoHA™ Methacrylated Hyaluronic acid can be used to form hydrogels for ex-vivo engineering of autologous cartilage tissue[1] or as a mesenchymal stem cell carrier in cartilage repair[2]. Because the stiffness can be widely adjusted by altering concentration or UV-light exposure, methacrylated HA has been used to measure the effects of matrix stiffness on cell phenotype and function[3][4]. Methacrylated HA can be used for 3D bioprinting (extrusion[5], inkjet[5] and photolithographic[6]) to create structures that promote osteogenic differentiation of MSC’s[7]. The high tunability of hyaluronic acid methacrylate allows it to be mixed with, and reinforce other types of hydrogels (such as collagen, or gelatin methacrylate)[8]. References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717235/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627486/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541838/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447944/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615317/ https://www.ncbi.nlm.nih.gov/pubmed/21773726/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460858/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748291/

PhotoHA™ is 100 mg of lyophilized methacrylated hyaluronic acid (GM-HA). PhotoHA™ provides 3D hyaluronic acid hydrogels with the unique attributes to be prepared at various concentrations and photocrosslinked to provide various gel stiffness. GM-HA forms softer hydrogels than HAMA.

Product Description Advanced BioMatrix offers PhotoHA™-Soft, a methacrylated hyaluronic acid (GMHA) for photocrosslinkable hydrogels. PhotoHA-Soft forms softer hydrogels than PhotoHA-Stiff. These hydrogels provide native-like 3D HA gels with the unique attributes to be prepared at various concentrations and photocrosslinked to provide various gel stiffness. Item Catalog Number Package Size Storage Temperature Methacrylated Hyaluronic Acid #5388 100 mg -20°C Hyaluronic acid is the most abundant glycosaminoglycan in the body being an important component of several tissues throughout the body. While it is abundant in extracellular matrices, hyaluronic acid also contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions. For the majority of cell types, it is recommended to add additional ECM proteins to the hyaluronic acid hydrogels. The proteins provide important cell binding sites. Once solubilized, the PhotoHA™ can be stored at 2-10°C for 1 month.