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产品描述
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Storage:
- Store the product at -20°C for long-term stability.
- Keep it away from light and moisture to preserve its integrity.
- Once opened, use within 6 months and store reconstituted solutions at 4°C for short-term use.
- Avoid repeated freeze-thaw cycles to maintain product efficacy.
Product Description:
- MC-Val-Cit-PAB-MMAE is a potent cytotoxic agent used in antibody-drug conjugates (ADCs).
- This compound integrates a valine-citrulline linker designed for stability and controlled release upon enzymatic cleavage.
- It is conjugated with monomethyl auristatin E (MMAE), a synthetic antineoplastic agent that disrupts microtubule function, leading to cell cycle arrest and apoptosis.
Key Features:
- High Potency: MMAE is highly effective at inducing cell death, making it a valuable component in targeted cancer therapies.
- Targeted Delivery: The valine-citrulline linker ensures that MMAE is released specifically in target cells, reducing off-target effects.
- Versatility: Suitable for conjugation with various antibodies, allowing customization for specific cancer targets.
- Stability: The linker provides enhanced stability in systemic circulation, ensuring the active drug reaches the intended site of action.
What's Included:
- Vial containing [specific quantity] of MC-Val-Cit-PAB-MMAE.
- Product datasheet with detailed specifications and handling instructions.
- Certificate of Analysis (CoA) guaranteeing product quality and purity.
- Safety data sheet (SDS) outlining handling precautions and safety measures.
Applications:
- Cancer Research: Primarily used in the development of ADCs for targeted cancer therapy.
- Pharmaceutical Development: A key component in preclinical studies for novel therapeutic agents.
- Bioconjugation Studies: Useful in research focusing on drug delivery systems and linker technologies.
- Toxicology Testing: Evaluating the safety and efficacy of new drug formulations.
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This structured information provides a comprehensive view of MC-Val-Cit-PAB-MMAE, highlighting its utility and best practices for handling and application. Adjust quantities and specific details based on the actual product specifications available.
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