Certainly! Below is a detailed supplement and improvement of product information for the biological product SK-MEL-5, focusing on the aspects you mentioned:

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SK-MEL-5 Product Information


Storage
- Temperature: Store SK-MEL-5 cells in liquid nitrogen vapor phase or at -150°C for optimal long-term preservation.
- Conditions: Ensure the storage environment is stable and monitored to prevent temperature fluctuations that could affect cell viability.
- Handling: When retrieving cells, minimize exposure to ambient temperatures by using pre-chilled instruments and performing operations swiftly.


Product Description
- Overview: SK-MEL-5 is a human melanoma cell line derived from the skin tissue of a Caucasian male patient. It is commonly used in cancer research, particularly for studies involving melanoma.
- Morphology: These cells exhibit an adherent growth pattern with a spindle-shaped morphology, typical of melanoma cells.
- Origin: The cell line was established from metastatic melanoma, providing a relevant model for studying tumor progression and drug response.


Key Features
- Genetic Profile: SK-MEL-5 cells possess mutations in genes such as BRAF, which are critical for studying targeted melanoma therapies.
- Research Relevance: Widely used in research on melanoma, including studies on drug resistance, gene expression, and cancer cell signaling pathways.
- Growth Characteristics: Known for their rapid growth rate, making them suitable for experiments requiring substantial cell yields.


What's Included
- Cell Vial: Each purchase includes a vial containing a specified number of viable SK-MEL-5 cells, typically around 1 million cells per vial.
- Certificate of Analysis: A detailed report confirming the genetic and phenotypic characteristics of the SK-MEL-5 cell line.
- User Manual: Comprehensive guidelines for thawing, culturing, and maintaining the cells, along with troubleshooting tips for common issues.


Applications
- Cancer Research: Utilized extensively in melanoma research to understand tumor biology and test anti-cancer drugs.
- Drug Development: A model for screening and evaluating the efficacy of new therapeutics targeting melanoma-specific pathways.
- Genetic Studies: Ideal for investigating genetic mutations and their role in melanoma progression and treatment response.
- Immunology: Used in studies exploring immune evasion mechanisms of melanoma cells, contributing to immunotherapy research.

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By supplementing the product information in these areas, researchers and users of SK-MEL-5 cells can better understand the product's potential and how to effectively utilize it in their work.